The Molecular Virulence of Legionnaires' Disease Bacterium.

Legionella pneumophila, a facultative intracellular pathogen is responsible for nigh 85% of cases of the legionelloses Legionnaires disease and Pontiac fever (Dowling et al., 1992; Fields, 1997). These ar a consequent of the accompaniment that man has created additional environmental reservoirs for these opportunistic pathogens, providing them with a heart by which they can be disseminated in aerosols and open to mankind (Fields, 1997; Shuman et al., 1998). While both forms of legionellosis be caused by dream of commensurate numbers of aerosolised legionellae by a subject soldiers (Fields 1997), Pontiac fever which is the non pneumonic and less severe kind of unwellness is not provoked by tissue invasion so it may be caused by strains of Legionella incapable of intracellular multiplication (Dowling et al., 1992). Furthermore, it may involve a contact-dependent cytotoxic lurch up on the host cell surface (Husmann and Johnson, 1994). These bacteria atomic number 18 char acterised as gram negative, aerophilic rods (Fields, 1997) and possess a champion flagellum with a 47kDa strand subunit, the presence of which predicts virulence (Bosshardt et al., 1997). In the environment, legionellae are endosymbionts of fresh water phylum Protozoa (Byrne and Swanson, 1998), thus they obtain their nutrients from, and multiply in an intracellular environment. At the same time they are ubiquitous in freshwater environments, present at low concentrations in these aquatic reservoirs (Fields, 1997). so the bacteria must have or so delegacy to be able to adapt for its pick in distinguishable conditions (Byrne and Swanson, 1998).

For example, Legionella are susceptible to UV light, and plasmids mediating opposi! te to UV radiation may be crucial in the pathogens survival in both natural and manmade water systems (Tully, 1993). Byrne has suggested that when nutrients are massive in an intracellular environment, L. pneumophila are dedicated to reverberation and do not express factors correlated with virulence. When nutrients become... Having a medical background, this is really nice, my be a little overwhelming for the layman person. very(prenominal) nice work. Would be nice to have the preference scalawag with this essay, too; please. If you want to get a sound essay, graze it on our website: OrderEssay.net

If you want to get a full information about our service, visit our page: write my essay